Forum:

Mahyar Etminan, Sudeep Gill, Mark FitzGerald, and Ali Samii

Challenges and Opportunities for Pharmacoepidemiology in Drug-Therapy Decision Making
J Clin Pharmacol 2006 46: 6. [Abstract] [Full Text] [PDF]  

Therapeutic Review:

Amita Joshi, Robert Bauer, Peter Kuebler, Mark White, Cecelia Leddy, Peter Compton, Marvin Garovoy, Paul Kwon, Patricia Walicke, and Russell Dedrick

An Overview of the Pharmacokinetics and Pharmacodynamics of Efalizumab: A Monoclonal Antibody Approved for Use in Psoriasis
J Clin Pharmacol 2006 46: 10. [Abstract] [Full Text] [PDF]  

Clinical Studies:

James S. Kalus, Craig I. Coleman, and C. Michael White

The Impact of Suppressing the Renin-Angiotensin System on Atrial Fibrillation
J Clin Pharmacol 2006 46: 21. [Abstract] [Full Text] [PDF]  

Pharmacokinetics:

Candace Bramson, Daniele Ouellet, Doina Roman, Edward Randinitis, and Mark J. Gardner

A Single-Dose Pharmacokinetic Study of Lasofoxifene in Healthy Volunteers and Subjects With Mild and Moderate Hepatic Impairment
J Clin Pharmacol 2006 46: 29. [Abstract] [Full Text] [PDF]  

Anne Paccaly, Annke Frick, Shashank Rohatagi, Jingli Liu, Umesh Shukla, Ronald Rosenburg, Markus Hinder, and Bradford K. Jensen

Pharmacokinetics of Otamixaban, a Direct Factor Xa Inhibitor, in Healthy Male Subjects: Pharmacokinetic Model Development for Phase Simulation of Exposure
J Clin Pharmacol 2006 46: 37. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Pharmacodynamics:

Anne Paccaly, Annke Frick, Marie-Laure Ozoux, Valeria Chu, Ronald Rosenburg, Markus Hinder, Umesh Shukla, and Bradford K. Jensen

Pharmacokinetic/Pharmacodynamic Relationships for Otamixaban, a Direct Factor Xa Inhibitor, in Healthy Subjects
J Clin Pharmacol 2006 46: 45. [Abstract] [Full Text] [PDF]  

Mark Gardner, Ann Taylor, Greg Wei, Albert Calcagni, Jr, Barbara Duncan, and Ashley Milton

Clinical Pharmacology of Multiple Doses of Lasofoxifene in Postmenopausal Women
J Clin Pharmacol 2006 46: 52. [Abstract] [Full Text] [PDF]  

Ryuichi Ogawa, Ryoji Kishi, Kiyoshi Mihara, Harumi Takahashi, Akihiko Takagi, Naoki Matsumoto, Keisou Masuhara, Kiyoshi Nakazawa, Fumihiko Miyake, Shinichi Kobayashi, and Hirotoshi Echizen

Population Pharmacokinetic and Pharmacodynamic Analysis of a Class IC Antiarrhythmic, Pilsicainide, in Patients With Cardiac Arrhythmias
J Clin Pharmacol 2006 46: 59. [Abstract] [Full Text] [PDF]  

Xiaoli Du, Chonghua Li, Joseph L. Kuti, Charles H. Nightingale, and David P. Nicolau

Population Pharmacokinetics and Pharmacodynamics of Meropenem in Pediatric Patients
J Clin Pharmacol 2006 46: 69. [Abstract] [Full Text] [PDF]  

Timothy H. Mathew, Charles Van Buren, Barry D. Kahan, Khalid Butt, Sundaram Hariharan, James J. Zimmerman for the Rapamune 309 Study Group

A Comparative Study of Sirolimus Tablet Versus Oral Solution for Prophylaxis of Acute Renal Allograft Rejection
J Clin Pharmacol 2006 46: 76. [Abstract] [Full Text] [PDF]  

Reza Khosravan, Brian A. Grabowski, Michael D. Mayer, Jing-Tao Wu, Nancy Joseph-Ridge, and Laurent Vernillet

The Effect of Mild and Moderate Hepatic Impairment on Pharmacokinetics, Pharmacodynamics, and Safety of Febuxostat, a Novel Nonpurine Selective Inhibitor of Xanthine Oxidase
J Clin Pharmacol 2006 46: 88. [Abstract] [Full Text] [PDF]  

Drug Metabolism:

Joseph D. Ma, Anne N. Nafziger, Gerry Rhodes, Siyu Liu, Anne M. Gartung, and Joseph S. Bertino, Jr

The Effect of Oral Pleconaril on Hepatic Cytochrome P450 3A Activity in Healthy Adults Using Intravenous Midazolam as a Probe
J Clin Pharmacol 2006 46: 103. [Abstract] [Full Text] [PDF]  

Drug Interactions:

Ji-Young Park, Kyoung-Ah Kim, Pil-Whan Park, and Jong-Myung Ha

Effect of High-Dose Aspirin on CYP2E1 Activity in Healthy Subjects Measured Using Chlorzoxazone as a Probe
J Clin Pharmacol 2006 46: 109. [Abstract] [Full Text] [PDF]  

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